# OnCo record myc (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/myc/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "myc" ;
  schema:name "MYC"@en ;
  schema:description "MYC is the most commonly amplified cancer gene, a master switch that turns on thousands of growth genes. It has no pocket for a conventional drug, so it remained 'undruggable' for 40 years; the first direct MYC drugs finally entered trials in the 2020s."@en ;
  schema:url <https://onco.cc/pathways/myc/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Myc> ;
  owl:sameAs <http://www.wikidata.org/entity/Q420267> ;
  schema:citation <https://doi.org/10.1038/s41571-021-00549-2>, <https://doi.org/10.1038/s41591-024-02875-1> ;
  onco:tag "mechanism" ;
  onco:cancers <https://onco.cc/cancers/neuroblastoma/>, <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:targets <https://onco.cc/targets/cd47/>, <https://onco.cc/targets/kras/> ;
  onco:institutions <https://onco.cc/institutions/vall-dhebron/>, <https://onco.cc/institutions/ucsf/>, <https://onco.cc/institutions/dana-farber/>, <https://onco.cc/institutions/cold-spring-harbor/> ;
  onco:pathways <https://onco.cc/pathways/wnt/>, <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/pathways/notch/>, <https://onco.cc/pathways/cancer-metabolism/>, <https://onco.cc/pathways/mrna-translation-eif4f/>, <https://onco.cc/pathways/rna-splicing/> ;
  onco:terms <https://onco.cc/terms/mycn-amplification/>, <https://onco.cc/terms/sustaining-proliferative-signaling/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-dhanasekaran-nat-rev-clin-oncol/>, <https://onco.cc/key-papers/paper-brown-nat-med/> .