# OnCo record myeloid-leukaemia-of-down-syndrome (cancer). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/cancers/myeloid-leukaemia-of-down-syndrome/>
  a schema:MedicalCondition ;
  onco:kind "cancer" ;
  schema:identifier "myeloid-leukaemia-of-down-syndrome" ;
  schema:name "Myeloid leukaemia of Down syndrome"@en ;
  schema:alternateName "ML-DS"@en, "Myeloid leukemia of Down syndrome"@en, "Myeloid leukaemia associated with Down syndrome"@en, "Down syndrome acute megakaryoblastic leukaemia"@en, "DS-AMKL"@en, "Myeloid leukaemia of Down syndrome (GATA1-mutated; reduced-intensity chemotherapy)"@en ;
  schema:description "Myeloid leukaemia of Down syndrome is a form of acute myeloid leukaemia in young children with Down syndrome, driven by a GATA1 mutation on top of the extra chromosome 21 and often preceded by a transient leukaemia-like illness in the newborn. Its cells are unusually sensitive to chemotherapy, so children are cured about nine times in ten with gentler treatment than other childhood leukaemia."@en ;
  schema:url <https://onco.cc/cancers/myeloid-leukaemia-of-down-syndrome/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Transient_myeloproliferative_disease> ;
  schema:citation <https://www.cancer.gov/types/leukemia/patient/child-aml-treatment-pdq>, <https://doi.org/10.1038/s41375-022-01613-1>, <https://doi.org/10.1182/blood-2017-01-764324>, <https://doi.org/10.1615/critrevoncog.v16.i1-2.40> ;
  onco:tag "subtype-page", "wave4", "haematologic", "rare" ;
  onco:related <https://onco.cc/cancers/aml-paediatric/>, <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/childhood-cancers/>, <https://onco.cc/cancers/mixed-phenotype-acute-leukaemia/> ;
  onco:technologies <https://onco.cc/technologies/mrd-testing/> ;
  onco:targets <https://onco.cc/targets/gata1/> ;
  onco:drugs <https://onco.cc/drugs/cytarabine/>, <https://onco.cc/drugs/daunorubicin/> ;
  onco:trials <https://onco.cc/trials/nct02521493/> ;
  onco:standardOfCare <https://onco.cc/drugs/cytarabine/>, <https://onco.cc/drugs/daunorubicin/>, <https://onco.cc/technologies/mrd-testing/>, <https://onco.cc/cancers/aml-paediatric/>, <https://onco.cc/trials/nct02521493/> .