# OnCo record myeloid-suppression-axis (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/myeloid-suppression-axis/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "myeloid-suppression-axis" ;
  schema:name "Myeloid suppression: TAMs, MDSCs & don't-eat-me signals"@en ;
  schema:description "Tumours recruit the body's clean-up cells (macrophages and immature myeloid cells) and re-train them as bodyguards. They switch off T cells, build vessels, and, when a therapeutic antibody flags a cancer cell for eating, are told 'don't eat me' by CD47 on its surface."@en ;
  schema:url <https://onco.cc/pathways/myeloid-suppression-axis/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Tumor-associated_macrophage> ;
  schema:citation <https://doi.org/10.1038/s41577-019-0127-6> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:technologies <https://onco.cc/technologies/car-nk-macrophage/>, <https://onco.cc/technologies/trained-innate-immunity/>, <https://onco.cc/technologies/bcg-and-intravesical-therapy/>, <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/monoclonal-antibody/> ;
  onco:targets <https://onco.cc/targets/csf1r/>, <https://onco.cc/targets/cd47/>, <https://onco.cc/targets/pdl1/>, <https://onco.cc/targets/vegf/>, <https://onco.cc/targets/vista/>, <https://onco.cc/targets/cxcr4/> ;
  onco:drugs <https://onco.cc/drugs/pexidartinib/>, <https://onco.cc/drugs/vimseltinib/>, <https://onco.cc/drugs/magrolimab/>, <https://onco.cc/drugs/bcg-intravesical/> ;
  onco:pathways <https://onco.cc/pathways/tumor-microenvironment/>, <https://onco.cc/pathways/nutrient-competition-tme/>, <https://onco.cc/pathways/angiogenic-switch/>, <https://onco.cc/pathways/myc/>, <https://onco.cc/pathways/jak-stat/> ;
  onco:terms <https://onco.cc/terms/tumor-associated-macrophages/>, <https://onco.cc/terms/myeloid-derived-suppressor-cells/>, <https://onco.cc/terms/fc-effector/>, <https://onco.cc/terms/immune-exclusion/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tme-immunosuppression/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-denardo-nat-rev-immunol/> .