# OnCo record national-lung-matrix-trial (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/national-lung-matrix-trial/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "national-lung-matrix-trial", "NCT02664935" ;
  schema:name "National Lung Matrix Trial"@en ;
  schema:alternateName "NLMT"@en, "Lung Matrix"@en, "CRUK Stratified Medicine Programme 2"@en ;
  schema:description "The National Lung Matrix Trial was the United Kingdom's umbrella trial in lung cancer: thousands of patients were screened through the NHS and those with one of 22 rare genetic changes were offered a matching drug. Most cohorts did not clear the bar, which taught the field how hard single-target matching is outside the strongest drivers."@en ;
  schema:url <https://onco.cc/trials/national-lung-matrix-trial/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT02664935>, <https://doi.org/10.1038/s41586-020-2481-8> ;
  onco:status "completed" ;
  onco:phase "2" ;
  schema:startDate "2015-05-13" ;
  onco:cancers <https://onco.cc/cancers/nsclc/> ;
  onco:technologies <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/cdk46-inhibitor/>, <https://onco.cc/technologies/pi3k-akt-mtor-inhibitors/> ;
  onco:drugs <https://onco.cc/drugs/palbociclib/>, <https://onco.cc/drugs/crizotinib/>, <https://onco.cc/drugs/selumetinib/>, <https://onco.cc/drugs/docetaxel/>, <https://onco.cc/drugs/capivasertib/>, <https://onco.cc/drugs/osimertinib/>, <https://onco.cc/drugs/durvalumab/>, <https://onco.cc/drugs/vistusertib/> ;
  onco:companies <https://onco.cc/companies/astrazeneca/>, <https://onco.cc/companies/pfizer/> ;
  onco:institutions <https://onco.cc/institutions/birmingham-cancer-centre/>, <https://onco.cc/institutions/cruk/> ;
  onco:terms <https://onco.cc/terms/master-protocol/>, <https://onco.cc/terms/seamless-adaptive/>, <https://onco.cc/terms/basket-umbrella-platform/> ;
  onco:people <https://onco.cc/people/gary-middleton/>, <https://onco.cc/people/sanjay-popat/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-trial-design/>, <https://onco.cc/bottlenecks/b-trial-enrolment/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-middleton-nature/> .