# OnCo record nct05323955 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/nct05323955/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "nct05323955", "NCT05323955" ;
  schema:name "Tucatinib after isolated brain progression"@en ;
  schema:alternateName "Secondary BRain Metastases Prevention After Isolated Intracranial Progression on Trastuzumab/Pertuzumab or T-DM1 in Patients With aDvanced Human Epidermal Growth Factor Receptor 2+ brEast Cancer With the Addition of Tucatinib"@en ;
  schema:description "This study adds tucatinib after local treatment for cancer progression in the brain while continuing selected HER2-directed therapy. It follows further progression in people whose cancer outside the brain remains controlled."@en ;
  schema:url <https://onco.cc/trials/nct05323955/> ;
  schema:dateModified "2026-10-10"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT05323955>, <https://clinicaltrials.ucsf.edu/trial/NCT05323955> ;
  onco:status "active" ;
  onco:tag "ucsf-breast-coverage", "interventional" ;
  onco:phase "2" ;
  schema:startDate "2023-03-23" ;
  onco:cancers <https://onco.cc/cancers/breast-cancer/> ;
  onco:drugs <https://onco.cc/drugs/pertuzumab/>, <https://onco.cc/drugs/trastuzumab/>, <https://onco.cc/drugs/trastuzumab-emtansine/>, <https://onco.cc/drugs/tucatinib/> ;
  onco:institutions <https://onco.cc/institutions/ucsf/> .