# OnCo record neoadjuvant-io-dmmr (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/neoadjuvant-io-dmmr/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "neoadjuvant-io-dmmr" ;
  schema:name "Neoadjuvant checkpoint inhibitor → surgery (or no surgery) in dMMR colorectal cancer"@en ;
  schema:description "Test the tumour for a broken DNA spell-checker; if it has one, immunotherapy before surgery melts most tumours and in the rectum can replace surgery altogether."@en ;
  schema:url <https://onco.cc/pairings/neoadjuvant-io-dmmr/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT03026140>, <https://clinicaltrials.gov/study/NCT05723562> ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:drugs <https://onco.cc/drugs/nivolumab/>, <https://onco.cc/drugs/ipilimumab/>, <https://onco.cc/drugs/dostarlimab/>, <https://onco.cc/drugs/atezolizumab/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/terms/neoadjuvant-adjuvant/>, <https://onco.cc/terms/clinical-complete-response/> ;
  onco:trials <https://onco.cc/trials/niche-2/>, <https://onco.cc/trials/azur-1/>, <https://onco.cc/trials/atomic/> ;
  onco:pairs <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/terms/msi/> .