# OnCo record netupitant-palonosetron (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/netupitant-palonosetron/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "netupitant-palonosetron" ;
  schema:name "Netupitant and palonosetron"@en ;
  schema:alternateName "NEPA"@en, "Fosnetupitant and palonosetron (intravenous)"@en, "Akynzeo" ;
  schema:description "Akynzeo combines two anti-sickness drugs in one capsule or infusion taken once before chemotherapy, so a single dose plus dexamethasone protects against both immediate and delayed vomiting."@en ;
  schema:url <https://onco.cc/drugs/netupitant-palonosetron/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Netupitant/palonosetron> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=netupitant>, <https://www.cancer.gov/about-cancer/treatment/drugs/netupitant-palonosetronhydrochloride>, <https://www.ema.europa.eu/en/medicines/human/EPAR/akynzeo> ;
  onco:status "approved" ;
  onco:tag "nci-list", "supportive" ;
  onco:modality "Fixed combination NK1 antagonist plus 5-HT3 antagonist (antiemetic)" ;
  onco:approval "US 2014: Acute and delayed chemotherapy-induced nausea and vomiting including highly emetogenic regimens, with dexamethasone (intravenous form 2018)", "EU 2015: Acute and delayed nausea and vomiting with highly and moderately emetogenic chemotherapy (Akynzeo)" ;
  onco:related <https://onco.cc/drugs/palonosetron/>, <https://onco.cc/drugs/aprepitant/> ;
  onco:technologies <https://onco.cc/technologies/antiemetic-therapy/> ;
  onco:companies <https://onco.cc/companies/helsinn/> ;
  onco:trials <https://onco.cc/trials/nct03367572/>, <https://onco.cc/trials/nct03668639/>, <https://onco.cc/trials/nct03386617/> .