# OnCo record neurofibromatosis-type-1 (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/neurofibromatosis-type-1/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "neurofibromatosis-type-1" ;
  schema:name "Neurofibromatosis type 1"@en ;
  schema:alternateName "neurofibromatosis type I"@en, "NF1 syndrome"@en, "NF1 neurofibromatosis"@en ;
  schema:description "Neurofibromatosis type 1 is an inherited condition, affecting about one in 2,000 to 2,500 babies, that causes nerve tumours called neurofibromas and raises the risk of some cancers. Regular check-ups find problems early, and two tablets now shrink the large plexiform neurofibromas that cannot be removed by surgery."@en ;
  schema:url <https://onco.cc/terms/neurofibromatosis-type-1/> ;
  schema:dateModified "2026-11-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Neurofibromatosis_type_I> ;
  schema:citation <https://doi.org/10.1016/j.eclinm.2022.101818>, <https://doi.org/10.1158/1078-0432.ccr-24-1611>, <https://doi.org/10.1158/1078-0432.ccr-17-0589>, <https://www.orpha.net/en/disease/detail/636>, <https://www.england.nhs.uk/wp-content/uploads/2018/08/rare-and-inherited-disease-national-genomics-test-directory-v9.xlsx> ;
  onco:tag "gap-fill", "hereditary" ;
  onco:cancers <https://onco.cc/cancers/optic-pathway-glioma/>, <https://onco.cc/cancers/malignant-peripheral-nerve-sheath-tumour/> ;
  onco:technologies <https://onco.cc/technologies/whole-body-mri/>, <https://onco.cc/technologies/germline-testing/> ;
  onco:targets <https://onco.cc/targets/nf1/> ;
  onco:drugs <https://onco.cc/drugs/selumetinib/>, <https://onco.cc/drugs/mirdametinib/> ;
  onco:terms <https://onco.cc/terms/hereditary-cancer-syndromes/> .