# OnCo record nf1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/nf1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "nf1" ;
  schema:name "NF1 (neurofibromin)"@en ;
  schema:alternateName "neurofibromin"@en, "neurofibromin 1"@en, "NF1" ;
  schema:description "NF1 makes neurofibromin, the protein that switches RAS off. People born with one faulty copy develop neurofibromatosis type 1, whose plexiform neurofibromas are now treated with the MEK inhibitors selumetinib and mirdametinib, which cut the RAS signal one step down."@en ;
  schema:url <https://onco.cc/targets/nf1/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7765>, <https://www.uniprot.org/uniprotkb/P21359/entry>, <https://www.ncbi.nlm.nih.gov/gene/4763> ;
  onco:tag "wave5-target" ;
  onco:targetClass "tumor-suppressor" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7765>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196712>, <https://www.uniprot.org/uniprotkb/P21359/entry>, <https://www.ncbi.nlm.nih.gov/gene/4763> ;
  onco:related <https://onco.cc/drugs/selumetinib/>, <https://onco.cc/drugs/mirdametinib/>, <https://onco.cc/targets/mek/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/nras/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/pathways/oncogene-activation-two-hit/> .