# OnCo record nfe2l2 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/nfe2l2/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "nfe2l2" ;
  schema:name "NFE2L2"@en ;
  schema:alternateName "NFE2 like bZIP transcription factor 2"@en, "Nuclear factor erythroid 2-related factor 2"@en, "NRF2"@en, "NRF-2"@en, "NFE2L2" ;
  schema:description "NFE2L2 (Nuclear factor erythroid 2-related factor 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer, Hepatocellular carcinoma, Head and neck squamous cell carcinoma and 5 more."@en ;
  schema:url <https://onco.cc/targets/nfe2l2/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7782>, <https://www.uniprot.org/uniprotkb/Q16236/entry>, <https://www.ncbi.nlm.nih.gov/gene/4780>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000116044> ;
  onco:tag "cancer-genes-wave" ;
  onco:targetClass "transcription" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7782>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000116044>, <https://www.uniprot.org/uniprotkb/Q16236/entry>, <https://www.ncbi.nlm.nih.gov/gene/4780> ;
  onco:related <https://onco.cc/collections/civic/>, <https://onco.cc/collections/open-targets/>, <https://onco.cc/collections/intogen/> ;
  onco:cancers <https://onco.cc/cancers/lung-cancer/>, <https://onco.cc/cancers/hcc/>, <https://onco.cc/cancers/head-and-neck/>, <https://onco.cc/cancers/urothelial/>, <https://onco.cc/cancers/esophageal/>, <https://onco.cc/cancers/endometrial/>, <https://onco.cc/cancers/cervical/>, <https://onco.cc/cancers/rcc/> ;
  onco:pathways <https://onco.cc/pathways/drug-efflux-pumps/>, <https://onco.cc/pathways/hepatocellular-carcinoma-signalling/>, <https://onco.cc/pathways/keap1-nrf2/> .