# OnCo record niche-2 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/niche-2/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "niche-2", "NCT03026140" ;
  schema:name "NICHE-2"@en ;
  schema:description "In NICHE-2, four weeks of immunotherapy before surgery wiped out most mismatch-repair-deficient colon cancers, and nobody had relapsed three years later."@en ;
  schema:url <https://onco.cc/trials/niche-2/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT03026140>, <https://www.nejm.org/doi/abs/10.1056/NEJMoa2400634> ;
  onco:status "positive" ;
  onco:phase "2" ;
  schema:startDate "2017-03-29" ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/msi-high-colorectal/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:drugs <https://onco.cc/drugs/nivolumab/>, <https://onco.cc/drugs/ipilimumab/> ;
  onco:institutions <https://onco.cc/institutions/nki/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/terms/neoadjuvant-adjuvant/>, <https://onco.cc/terms/pcr/> ;
  onco:trials <https://onco.cc/trials/nct05855200/>, <https://onco.cc/trials/foxtrot/> ;
  onco:people <https://onco.cc/people/myriam-chalabi/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-le-mmr-deficiency-pd1-nejm-2015/>, <https://onco.cc/key-papers/paper-moreira-lynch-syndrome-identification-jama-2012/>, <https://onco.cc/key-papers/paper-niche-2-nat-med-2020/> .