# OnCo record nirogacestat (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/nirogacestat/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "nirogacestat" ;
  schema:name "Nirogacestat"@en ;
  schema:description "Nirogacestat is the first approved medicine for desmoid tumours, locally invasive growths that do not spread but can be crippling; it works by blocking Notch signalling."@en ;
  schema:url <https://onco.cc/drugs/nirogacestat/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Nirogacestat> ;
  owl:sameAs <http://www.wikidata.org/entity/Q27088329> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Nirogacestat> ;
  onco:status "approved" ;
  onco:modality "Small-molecule gamma-secretase inhibitor" ;
  schema:alternateName "Ogsiveo" ;
  onco:approval "US 2023: Progressing desmoid tumours requiring systemic treatment", "EU 2025: Progressing desmoid tumours" ;
  onco:cancers <https://onco.cc/cancers/sarcoma/>, <https://onco.cc/cancers/desmoid-tumour/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/gamma-secretase-inhibitors/> ;
  onco:companies <https://onco.cc/companies/springworks/> ;
  onco:pathways <https://onco.cc/pathways/wnt/> ;
  onco:trials <https://onco.cc/trials/defi/>, <https://onco.cc/trials/nct07084896/>, <https://onco.cc/trials/nct07170644/>, <https://onco.cc/trials/nct07150091/>, <https://onco.cc/trials/nct07150104/> .