# OnCo record norton-simon-hypothesis (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/norton-simon-hypothesis/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "norton-simon-hypothesis" ;
  schema:name "Norton-Simon hypothesis and dose-dense chemotherapy"@en ;
  schema:description "Because tumours regrow fastest when small, the best way to finish them is to give the same chemotherapy doses closer together. The idea, from Larry Norton and Richard Simon, was proved in breast cancer by the CALGB 9741 trial and made two-weekly chemotherapy a standard."@en ;
  schema:url <https://onco.cc/technologies/norton-simon-hypothesis/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://doi.org/10.1200/JCO.2003.09.081>, <https://doi.org/10.1016/S0140-6736(18)33137-4> ;
  onco:status "established" ;
  onco:tag "mathematical-model" ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/breast-her2-positive/>, <https://onco.cc/cancers/tnbc/> ;
  onco:sections <https://onco.cc/fronts/ai-computation/>, <https://onco.cc/fronts/drug-discovery/> ;
  onco:technologies <https://onco.cc/technologies/gompertzian-growth-model/>, <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/g-csf-growth-factors/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-early-breast-cancer-trialists-collaborative-group-ebctcg-lancet-2019/>, <https://onco.cc/key-papers/paper-citron-j-clin-oncol/> .