# OnCo record notch (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/notch/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "notch" ;
  schema:name "Notch signalling"@en ;
  schema:description "A cell-to-cell contact signal that decides cell fate. It drives T-cell leukaemia when mutated on, acts as a tumour suppressor in some squamous cancers when lost, and its ligand DLL3 became a drug target in small-cell lung cancer."@en ;
  schema:url <https://onco.cc/pathways/notch/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Notch_signaling_pathway> ;
  owl:sameAs <http://www.wikidata.org/entity/Q904082> ;
  schema:citation <https://doi.org/10.1146/annurev-pathol-052016-100127> ;
  onco:tag "mechanism" ;
  onco:cancers <https://onco.cc/cancers/sclc/>, <https://onco.cc/cancers/all-leukemia/>, <https://onco.cc/cancers/cll/>, <https://onco.cc/cancers/head-and-neck/>, <https://onco.cc/cancers/tnbc/> ;
  onco:targets <https://onco.cc/targets/dll3/> ;
  onco:drugs <https://onco.cc/drugs/tarlatamab/>, <https://onco.cc/drugs/nirogacestat/> ;
  onco:institutions <https://onco.cc/institutions/dana-farber/>, <https://onco.cc/institutions/penn-abramson/> ;
  onco:pathways <https://onco.cc/pathways/cancer-stem-cells-plasticity/>, <https://onco.cc/pathways/myc/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-aster-annu-rev-pathol/> .