# OnCo record nrg1-fusion (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/nrg1-fusion/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "nrg1-fusion" ;
  schema:name "NRG1 gene fusion"@en ;
  schema:alternateName "NRG1 fusion"@en, "neuregulin 1 fusion"@en, "NRG1 gene rearrangement"@en, "CD74-NRG1"@en, "CD74::NRG1"@en, "SLC3A2-NRG1"@en, "NRG1-rearranged"@en, "NRG1+"@en ;
  schema:description "A rare fusion that joins the neuregulin 1 gene to a partner, leaving the HER3 ligand stuck on the cell surface where it switches HER3 on continuously. It is found in a small percentage of lung adenocarcinomas, particularly invasive mucinous adenocarcinoma in people who have never smoked, and in pancreatic and biliary cancers, and zenocutuzumab is approved for it."@en ;
  schema:url <https://onco.cc/biomarkers/nrg1-fusion/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=203daea4-fc87-40a4-a92f-ba2351b16de1>, <https://doi.org/10.1158/1078-0432.CCR-19-0160>, <https://doi.org/10.1158/2159-8290.CD-13-0633>, <https://www.cbioportal.org/study/summary?id=luad_mskcc_2023_met_organotropism> ;
  onco:tag "biomarker", "fusion" ;
  onco:related <https://onco.cc/biomarkers/ntrk-fusion/>, <https://onco.cc/biomarkers/ret-fusion/>, <https://onco.cc/biomarkers/ros1-fusion/>, <https://onco.cc/biomarkers/her2-mutation/> ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/cholangiocarcinoma/>, <https://onco.cc/cancers/invasive-mucinous-adenocarcinoma-lung/>, <https://onco.cc/cancers/lung-cancer/> ;
  onco:technologies <https://onco.cc/technologies/rna-seq/>, <https://onco.cc/technologies/cgp/> ;
  onco:targets <https://onco.cc/targets/nrg1/>, <https://onco.cc/targets/her2/> ;
  onco:drugs <https://onco.cc/drugs/zenocutuzumab/> ;
  onco:pathways <https://onco.cc/pathways/rtk-activation/>, <https://onco.cc/pathways/pi3k-akt-mtor/> ;
  onco:terms <https://onco.cc/terms/gene-fusion/>, <https://onco.cc/terms/tumour-agnostic/>, <https://onco.cc/terms/never-smoker-lung-cancer/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-jonna-nrg1-fusions-solid-tumours-ccr-2019/>, <https://onco.cc/key-papers/paper-fernandez-cuesta-cd74-nrg1-fusion-lung-cancer-discov-2014/> .