# OnCo record nut-carcinoma (cancer). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/cancers/nut-carcinoma/>
  a schema:MedicalCondition ;
  onco:kind "cancer" ;
  schema:identifier "nut-carcinoma" ;
  schema:name "NUT carcinoma (midline carcinoma with NUTM1 rearrangement)"@en ;
  schema:alternateName "NUT midline carcinoma"@en, "Midline tract carcinoma with NUT gene changes"@en, "NMC"@en ;
  schema:description "NUT carcinoma is a fast-growing cancer of the midline of the body driven by a single fused gene, BRD4-NUTM1, that locks cells in an immature state. Chemotherapy and surgery rarely control it for long, but drugs that block the BET proteins the fusion depends on have produced responses and are the focus of trials."@en ;
  schema:url <https://onco.cc/cancers/nut-carcinoma/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/NUT_midline_carcinoma> ;
  schema:citation <https://www.cancer.gov/types/midline/patient-child-midline-tract-carcinoma-treatment-pdq>, <https://doi.org/10.1038/nature09504> ;
  onco:tag "nci-coverage", "rare", "head-and-neck", "paediatric" ;
  onco:technologies <https://onco.cc/technologies/epigenetic-drugs/>, <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/imrt-igrt/> ;
  onco:drugs <https://onco.cc/drugs/ifosfamide/>, <https://onco.cc/drugs/cisplatin/>, <https://onco.cc/drugs/etoposide/> ;
  onco:institutions <https://onco.cc/institutions/dana-farber/> ;
  onco:pathways <https://onco.cc/pathways/transcription-addiction/>, <https://onco.cc/pathways/epigenetic-reprogramming/>, <https://onco.cc/pathways/myc/> ;
  onco:terms <https://onco.cc/terms/gene-fusion/>, <https://onco.cc/terms/rare-cancers/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-rare-cancers/>, <https://onco.cc/bottlenecks/b-undruggable-targets/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-filippakopoulos-nature/> ;
  onco:pipeline <https://onco.cc/drugs/zen-3694/>, <https://onco.cc/trials/zen-3694-platinum-nut/>, <https://onco.cc/trials/zen-3694-abemaciclib-nut/>, <https://onco.cc/trials/cemiplimab-nut/>, <https://onco.cc/technologies/epigenetic-drugs/>, <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:standardOfCare <https://onco.cc/drugs/ifosfamide/>, <https://onco.cc/drugs/cisplatin/>, <https://onco.cc/technologies/imrt-igrt/>, <https://onco.cc/technologies/epigenetic-drugs/> .