# OnCo record nutrient-competition-tme (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/nutrient-competition-tme/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "nutrient-competition-tme" ;
  schema:name "Nutrient competition & metabolic immunosuppression"@en ;
  schema:description "Tumours and immune cells eat from the same plate. Cancer cells hoard glucose and glutamine, dump lactate and acid, and burn tryptophan and arginine into by-products that paralyse T cells. The tumour wins the food fight, and the immune system loses before it has fired a shot."@en ;
  schema:url <https://onco.cc/pathways/nutrient-competition-tme/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Tumor_microenvironment> ;
  schema:citation <https://doi.org/10.1016/j.cell.2015.08.016> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/metabolic-therapy/>, <https://onco.cc/technologies/armored-car/>, <https://onco.cc/technologies/hypoxia-activated-therapy/>, <https://onco.cc/technologies/fasting-mimicking-diet/> ;
  onco:targets <https://onco.cc/targets/cd73-adenosine/>, <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/csf1r/>, <https://onco.cc/targets/hif2a/>, <https://onco.cc/targets/vegf/> ;
  onco:drugs <https://onco.cc/drugs/epacadostat/>, <https://onco.cc/drugs/pembrolizumab/> ;
  onco:pathways <https://onco.cc/pathways/cancer-metabolism/>, <https://onco.cc/pathways/glutamine-metabolism/>, <https://onco.cc/pathways/tumor-microenvironment/>, <https://onco.cc/pathways/hif-vhl/>, <https://onco.cc/pathways/myeloid-suppression-axis/> ;
  onco:terms <https://onco.cc/terms/warburg-effect/>, <https://onco.cc/terms/myeloid-derived-suppressor-cells/>, <https://onco.cc/terms/tumor-associated-macrophages/>, <https://onco.cc/terms/cold-vs-hot/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tme-immunosuppression/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-chang-cell/> .