# OnCo record opt-in (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/opt-in/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "opt-in", "NCT04559139" ;
  schema:name "OPT-IN (EA2197)"@en ;
  schema:alternateName "OPT-IN"@en, "EA2197"@en, "Optimal Perioperative Therapy for Incidental Gallbladder Cancer"@en ;
  schema:description "OPT-IN is the American trial asking whether people whose gallbladder cancer was found by chance should have chemotherapy before their second operation or only after it. It is the first randomised test of neoadjuvant treatment in incidental gallbladder cancer and will report overall survival."@en ;
  schema:url <https://onco.cc/trials/opt-in/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT04559139>, <https://doi.org/10.1245/s10434-021-10277-7> ;
  onco:status "active" ;
  onco:phase "2/3" ;
  onco:related <https://onco.cc/trials/gain-igbc/> ;
  onco:cancers <https://onco.cc/cancers/gallbladder/>, <https://onco.cc/cancers/incidental-gallbladder-cancer/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/platinum/>, <https://onco.cc/technologies/gallbladder-cancer-surgery/> ;
  onco:drugs <https://onco.cc/drugs/gemcitabine-cisplatin/>, <https://onco.cc/drugs/gemcitabine/>, <https://onco.cc/drugs/cisplatin/> ;
  onco:institutions <https://onco.cc/institutions/ecog-acrin/> ;
  onco:terms <https://onco.cc/terms/radical-cholecystectomy/>, <https://onco.cc/terms/hepatectomy/>, <https://onco.cc/terms/lymphadenectomy/>, <https://onco.cc/terms/neoadjuvant-adjuvant/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-varshney-neoadjuvant-incidental-gallbladder-cancer-systematic-review-ahbps-2025/> .