# OnCo record oral-serd-plus-cdk46-after-esr1 (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/oral-serd-plus-cdk46-after-esr1/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "oral-serd-plus-cdk46-after-esr1" ;
  schema:name "Oral SERD + CDK4/6 inhibitor after ESR1 emergence"@en ;
  schema:description "When an ESR1 mutation appears, swap the aromatase inhibitor for an oral SERD and keep the CDK4/6 inhibitor going."@en ;
  schema:url <https://onco.cc/pairings/oral-serd-plus-cdk46-after-esr1/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT04964934>, <https://clinicaltrials.gov/study/NCT04975308> ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/> ;
  onco:drugs <https://onco.cc/drugs/camizestrant/>, <https://onco.cc/drugs/imlunestrant/>, <https://onco.cc/drugs/abemaciclib/> ;
  onco:terms <https://onco.cc/terms/esr1-mutation/> ;
  onco:trials <https://onco.cc/trials/serena-6/>, <https://onco.cc/trials/ember-3/> ;
  onco:pairs <https://onco.cc/drugs/camizestrant/>, <https://onco.cc/technologies/cdk46-inhibitor/> .