# OnCo record oral-targeted-therapy-drug-monitoring (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/oral-targeted-therapy-drug-monitoring/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "oral-targeted-therapy-drug-monitoring" ;
  schema:name "Blood-level monitoring of oral targeted cancer drugs"@en ;
  schema:alternateName "therapeutic drug monitoring of kinase inhibitors"@en, "TDM of oral targeted therapies"@en, "trough level monitoring"@en, "pharmacokinetically guided dosing of targeted therapy"@en ;
  schema:description "Cancer tablets such as kinase inhibitors are given at one dose for everyone, though the amount in the blood differs widely between people. A Dutch study of 600 patients measured trough levels and adjusted when they were low, cutting the share of people with too little drug by 39 per cent, but no trial has yet shown that this improves survival."@en ;
  schema:url <https://onco.cc/technologies/oral-targeted-therapy-drug-monitoring/> ;
  schema:dateModified "2026-10-20"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/j.annonc.2022.06.010> ;
  onco:status "emerging" ;
  onco:tag "precision", "evidence:insufficient" ;
  onco:related <https://onco.cc/ideas/idea-tr1-therapeutic-drug-monitoring-for-oral-tkis/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/>, <https://onco.cc/fronts/supportive-care/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/pkpd-modelling/>, <https://onco.cc/technologies/fluorouracil-pharmacokinetic-dosing/> ;
  onco:drugs <https://onco.cc/drugs/imatinib/> ;
  onco:terms <https://onco.cc/terms/pharmacokinetics/>, <https://onco.cc/terms/therapeutic-index/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-dose-optimisation/> .