# OnCo record organ-tropism-seed-soil (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/organ-tropism-seed-soil/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "organ-tropism-seed-soil" ;
  schema:name "Organ tropism: seed and soil"@en ;
  schema:description "Breast cancer goes to bone, lung, liver and brain; prostate cancer to bone; colon cancer to liver; uveal melanoma almost only to liver. Paget's 1889 idea still holds: where a cancer spreads depends on both the seed (the cell's programme) and the soil (the organ's welcome). Each soil has its own vicious cycle, and some are druggable."@en ;
  schema:url <https://onco.cc/pathways/organ-tropism-seed-soil/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Seed_and_soil_hypothesis> ;
  schema:citation <https://doi.org/10.1016/j.trecan.2015.07.009> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/uveal-melanoma/>, <https://onco.cc/cancers/ovarian/> ;
  onco:technologies <https://onco.cc/technologies/bone-modifying-agents/>, <https://onco.cc/technologies/sbrt/>, <https://onco.cc/technologies/hipec/>, <https://onco.cc/technologies/radioembolisation-tare/>, <https://onco.cc/technologies/liver-transplant-oncology/>, <https://onco.cc/technologies/whole-body-mri/>, <https://onco.cc/technologies/psma-pet/> ;
  onco:targets <https://onco.cc/targets/cxcr4/>, <https://onco.cc/targets/psma/>, <https://onco.cc/targets/her2/>, <https://onco.cc/targets/alk/> ;
  onco:drugs <https://onco.cc/drugs/radium-223/>, <https://onco.cc/drugs/pluvicto/>, <https://onco.cc/drugs/tucatinib/>, <https://onco.cc/drugs/lorlatinib/> ;
  onco:pathways <https://onco.cc/pathways/metastatic-cascade/>, <https://onco.cc/pathways/pre-metastatic-niche/>, <https://onco.cc/pathways/blood-brain-barrier-metastasis/>, <https://onco.cc/pathways/tgf-beta/>, <https://onco.cc/pathways/tumor-dormancy/> ;
  onco:terms <https://onco.cc/terms/oligometastatic/>, <https://onco.cc/terms/peritoneal-metastasis/>, <https://onco.cc/terms/her2-brain-metastases/>, <https://onco.cc/terms/pam50/>, <https://onco.cc/terms/blood-brain-barrier/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-metastasis-biology/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-obenauf-trends-cancer/> .