# OnCo record p53-cell-cycle (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/p53-cell-cycle/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "p53-cell-cycle" ;
  schema:name "p53 / RB / cell-cycle checkpoint"@en ;
  schema:description "The p53 and RB checkpoints are the cell's brakes. p53 senses damage and stops the cell from copying itself; RB holds the cell at the G1 gate until CDK4/6 unlocks it. Cancers cut these brakes."@en ;
  schema:url <https://onco.cc/pathways/p53-cell-cycle/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Cell_cycle_checkpoint> ;
  owl:sameAs <http://www.wikidata.org/entity/Q1068809> ;
  schema:citation <https://en.wikipedia.org/wiki/Cell_cycle_checkpoint> ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/sarcoma/>, <https://onco.cc/cancers/gallbladder/> ;
  onco:targets <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/cdk4-6/>, <https://onco.cc/targets/wee1/>, <https://onco.cc/targets/atr/> ;
  onco:drugs <https://onco.cc/drugs/palbociclib/>, <https://onco.cc/drugs/ribociclib/>, <https://onco.cc/drugs/abemaciclib/> .