# OnCo record p53-mdm2-axis (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/p53-mdm2-axis/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "p53-mdm2-axis" ;
  schema:name "The p53 network (guardian of the genome)"@en ;
  schema:description "p53 is the cell's emergency coordinator: DNA damage, oncogene stress or lack of oxygen switch it on, and it then pauses division, orders repairs, or triggers suicide or permanent retirement, while MDM2 keeps it off in healthy cells. About half of cancers mutate p53 outright, and sarcomas, gliomas, melanomas and retinoblastomas silence it instead by amplifying MDM2 or MDM4."@en ;
  schema:url <https://onco.cc/pathways/p53-mdm2-axis/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/P53> ;
  schema:citation <https://doi.org/10.1016/j.cell.2017.08.028> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:cancers <https://onco.cc/cancers/sarcoma/>, <https://onco.cc/cancers/cll/>, <https://onco.cc/cancers/mds/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/gallbladder/> ;
  onco:technologies <https://onco.cc/technologies/germline-testing/>, <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/synthetic-lethality-approaches/> ;
  onco:targets <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/mdm2/>, <https://onco.cc/targets/atr/>, <https://onco.cc/targets/wee1/>, <https://onco.cc/targets/bcl2/> ;
  onco:drugs <https://onco.cc/drugs/eprenetapopt/>, <https://onco.cc/drugs/venetoclax/> ;
  onco:pathways <https://onco.cc/pathways/p53-cell-cycle/>, <https://onco.cc/pathways/apoptosis-bcl2/>, <https://onco.cc/pathways/senescence/>, <https://onco.cc/pathways/replication-stress/> ;
  onco:terms <https://onco.cc/terms/li-fraumeni/>, <https://onco.cc/terms/del17p-tp53/>, <https://onco.cc/terms/evading-growth-suppressors/>, <https://onco.cc/terms/germline-vs-somatic/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-kastenhuber-cell/> .