# OnCo record pallas-penelope-b (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/pallas-penelope-b/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "pallas-penelope-b", "NCT02513394" ;
  schema:name "PALLAS & PENELOPE-B"@en ;
  schema:description "Two large trials found that adding palbociclib after surgery does not prevent recurrence, even though the same drug helps in metastatic disease."@en ;
  schema:url <https://onco.cc/trials/pallas-penelope-b/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT02513394> ;
  onco:status "negative" ;
  onco:tag "failure", "lesson:drug-not-class" ;
  onco:phase "3" ;
  schema:startDate "2015-08" ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/hr-positive-early-high-risk/> ;
  onco:technologies <https://onco.cc/technologies/cdk46-inhibitor/> ;
  onco:targets <https://onco.cc/targets/cdk4-6/> ;
  onco:drugs <https://onco.cc/drugs/palbociclib/> ;
  onco:companies <https://onco.cc/companies/abcsg/> ;
  onco:people <https://onco.cc/people/miguel-martin/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-pallas-penelope-b-lancet-oncol-2021/> .