# OnCo record paper-alexandrov-tobacco-smoking-mutational-signatures-science-2016 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-alexandrov-tobacco-smoking-mutational-signatures-science-2016/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-alexandrov-tobacco-smoking-mutational-signatures-science-2016" ;
  schema:name "Mutational signatures associated with tobacco smoking in human cancer"@en ;
  schema:description "Comparing more than five thousand cancers of the types smoking causes showed exactly how tobacco does its damage: in the tissues smoke touches directly it leaves a chemical fingerprint in the DNA, and elsewhere it acts more indirectly."@en ;
  schema:url <https://onco.cc/key-papers/paper-alexandrov-tobacco-smoking-mutational-signatures-science-2016/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1126/science.aag0299>, <https://pubmed.ncbi.nlm.nih.gov/27811275/> ;
  schema:sameAs <https://doi.org/10.1126/science.aag0299> ;
  schema:datePublished "2016"^^xsd:gYear ;
  schema:author "Alexandrov LB, Ju YS, Haase K, et al." ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/sclc/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/tp53/> ;
  onco:pathways <https://onco.cc/pathways/mutagenesis-signatures/>, <https://onco.cc/pathways/chemical-carcinogenesis-receptor-activation/>, <https://onco.cc/pathways/theories-of-cancer/> ;
  onco:terms <https://onco.cc/terms/mutational-signature/>, <https://onco.cc/terms/tmb/>, <https://onco.cc/terms/kras-mutation-subtypes/> ;
  onco:journals <https://onco.cc/journals/science/> .