# OnCo record paper-almoguera-kras-codon-12-pancreatic-cell-1988 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-almoguera-kras-codon-12-pancreatic-cell-1988/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-almoguera-kras-codon-12-pancreatic-cell-1988" ;
  schema:name "Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes"@en ;
  schema:description "The 1988 paper that found a mutation in the KRAS gene in 21 of 22 pancreatic cancers, establishing the single most common driver in the disease and the target it took 33 more years to hit."@en ;
  schema:url <https://onco.cc/key-papers/paper-almoguera-kras-codon-12-pancreatic-cell-1988/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/0092-8674(88)90571-5>, <https://pubmed.ncbi.nlm.nih.gov/2453289/> ;
  onco:tag "pancreatic-evidence" ;
  schema:sameAs <https://doi.org/10.1016/0092-8674(88)90571-5> ;
  schema:datePublished "1988"^^xsd:gYear ;
  schema:author "Almoguera C, Shibata D, Forrester K, et al." ;
  onco:related <https://onco.cc/roadmaps/kras-roadmap/>, <https://onco.cc/key-papers/paper-ostrem-kras-g12c-nature-2013/> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/> ;
  onco:targets <https://onco.cc/targets/kras/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:terms <https://onco.cc/terms/kras-mutation-subtypes/> ;
  onco:people <https://onco.cc/people/frank-mccormick/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/> ;
  onco:journals <https://onco.cc/journals/cell/> .