# OnCo record paper-amplify-acalabrutinib-venetoclax-nejm-2025 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-amplify-acalabrutinib-venetoclax-nejm-2025/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-amplify-acalabrutinib-venetoclax-nejm-2025" ;
  schema:name "AMPLIFY: fixed-duration acalabrutinib plus venetoclax, with or without obinutuzumab, versus chemo-immunotherapy in fit CLL patients"@en ;
  schema:description "In AMPLIFY, an all-oral, 14-month course of acalabrutinib plus venetoclax beat FCR or BR chemo-immunotherapy in fit CLL patients, offering a time-limited alternative to indefinite pills."@en ;
  schema:url <https://onco.cc/key-papers/paper-amplify-acalabrutinib-venetoclax-nejm-2025/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://pubmed.ncbi.nlm.nih.gov/?term=AMPLIFY%20acalabrutinib%20venetoclax%20obinutuzumab%20Brown%20NEJM%202025>, <https://clinicaltrials.gov/study/NCT03836261> ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa2409804> ;
  schema:datePublished "2025"^^xsd:gYear ;
  schema:author "Brown JR, Seymour JF, Jurczak W, et al." ;
  onco:related <https://onco.cc/pairings/btki-plus-venetoclax-fixed-duration/> ;
  onco:cancers <https://onco.cc/cancers/cll/> ;
  onco:targets <https://onco.cc/targets/btk/>, <https://onco.cc/targets/bcl2/>, <https://onco.cc/targets/cd20/> ;
  onco:drugs <https://onco.cc/drugs/acalabrutinib/>, <https://onco.cc/drugs/venetoclax/>, <https://onco.cc/drugs/obinutuzumab/> ;
  onco:companies <https://onco.cc/companies/astrazeneca/>, <https://onco.cc/companies/abbvie/> ;
  onco:terms <https://onco.cc/terms/mrd/>, <https://onco.cc/terms/pfs/>, <https://onco.cc/terms/del17p-tp53/> ;
  onco:trials <https://onco.cc/trials/amplify/>, <https://onco.cc/trials/cll13-gaia/>, <https://onco.cc/trials/glow/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-combination-space/>, <https://onco.cc/bottlenecks/b-drug-pricing/> ;
  onco:journals <https://onco.cc/journals/nejm/> .