# OnCo record paper-andre-checkmate-8hw-nivolumab-ipilimumab-nejm-2024 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-andre-checkmate-8hw-nivolumab-ipilimumab-nejm-2024/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-andre-checkmate-8hw-nivolumab-ipilimumab-nejm-2024" ;
  schema:name "Nivolumab plus ipilimumab in microsatellite-instability-high metastatic colorectal cancer (CheckMate 8HW)"@en ;
  schema:description "Two immunotherapy drugs together kept 72 percent of patients progression-free at two years against 14 percent on chemotherapy, the largest effect size of any first-line trial in colorectal cancer."@en ;
  schema:url <https://onco.cc/key-papers/paper-andre-checkmate-8hw-nivolumab-ipilimumab-nejm-2024/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2402141>, <https://pubmed.ncbi.nlm.nih.gov/39602630/> ;
  onco:tag "colorectal-evidence" ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa2402141> ;
  schema:datePublished "2024"^^xsd:gYear ;
  schema:author "André T, Elez E, Van Cutsem E, et al." ;
  onco:related <https://onco.cc/key-papers/paper-andre-keynote-177-pembrolizumab-msi-high-nejm-2020/>, <https://onco.cc/key-papers/paper-niche-2-neoadjuvant-colon-nejm-2024/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/msi-high-colorectal/> ;
  onco:sections <https://onco.cc/fronts/immunotherapy/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/ctla4/> ;
  onco:drugs <https://onco.cc/drugs/nivolumab/>, <https://onco.cc/drugs/ipilimumab/> ;
  onco:companies <https://onco.cc/companies/bms/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/targets/mmr/> ;
  onco:trials <https://onco.cc/trials/checkmate-8hw/> ;
  onco:people <https://onco.cc/people/thierry-andre/>, <https://onco.cc/people/eric-van-cutsem/>, <https://onco.cc/people/heinz-josef-lenz/>, <https://onco.cc/people/myriam-chalabi/>, <https://onco.cc/people/yoshino-takayuki/> ;
  onco:journals <https://onco.cc/journals/nejm/> .