# OnCo record paper-andre-keynote-177-pembrolizumab-msi-high-nejm-2020 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-andre-keynote-177-pembrolizumab-msi-high-nejm-2020/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-andre-keynote-177-pembrolizumab-msi-high-nejm-2020" ;
  schema:name "Pembrolizumab in microsatellite-instability-high advanced colorectal cancer (KEYNOTE-177)"@en ;
  schema:description "The randomised trial that replaced chemotherapy with a single antibody as the first treatment for the 5 percent of metastatic bowel cancers with a broken DNA spell-checker: 16.5 against 8.2 months without progression, and a quarter of the severe side effects."@en ;
  schema:url <https://onco.cc/key-papers/paper-andre-keynote-177-pembrolizumab-msi-high-nejm-2020/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2017699>, <https://pubmed.ncbi.nlm.nih.gov/33264544/>, <https://www.annalsofoncology.org/article/S0923-7534(24)04949-4/fulltext> ;
  onco:tag "colorectal-evidence" ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa2017699> ;
  schema:datePublished "2020"^^xsd:gYear ;
  schema:author "André T, Shiu KK, Kim TW, et al." ;
  onco:related <https://onco.cc/key-papers/paper-le-pd1-blockade-mismatch-repair-deficiency-nejm-2015/>, <https://onco.cc/key-papers/paper-andre-checkmate-8hw-nivolumab-ipilimumab-nejm-2024/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/msi-high-colorectal/> ;
  onco:sections <https://onco.cc/fronts/immunotherapy/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/pd1/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/> ;
  onco:companies <https://onco.cc/companies/merck/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/targets/mmr/> ;
  onco:trials <https://onco.cc/trials/keynote-177/> ;
  onco:people <https://onco.cc/people/thierry-andre/>, <https://onco.cc/people/eric-van-cutsem/>, <https://onco.cc/people/yoshino-takayuki/>, <https://onco.cc/people/luis-diaz/> ;
  onco:journals <https://onco.cc/journals/nejm/> .