# OnCo record paper-arbour-kras-co-mutation-outcomes-ccr-2018 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-arbour-kras-co-mutation-outcomes-ccr-2018/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-arbour-kras-co-mutation-outcomes-ccr-2018" ;
  schema:name "Effects of co-occurring genomic alterations on outcomes in patients with KRAS-mutant non-small cell lung cancer"@en ;
  schema:description "Among 330 patients whose lung cancer carried a mutated KRAS gene, the ones who also had a broken KEAP1 gene did worse on every treatment: chemotherapy stopped working sooner and immunotherapy barely worked at all."@en ;
  schema:url <https://onco.cc/key-papers/paper-arbour-kras-co-mutation-outcomes-ccr-2018/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1158/1078-0432.CCR-17-1841>, <https://pubmed.ncbi.nlm.nih.gov/29089357/> ;
  schema:sameAs <https://doi.org/10.1158/1078-0432.CCR-17-1841> ;
  schema:datePublished "2018"^^xsd:gYear ;
  schema:author "Arbour KC, Jordan E, Kim HR, et al." ;
  onco:cancers <https://onco.cc/cancers/nsclc/> ;
  onco:technologies <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/keap1/>, <https://onco.cc/targets/nfe2l2/>, <https://onco.cc/targets/stk11/>, <https://onco.cc/targets/tp53/> ;
  onco:institutions <https://onco.cc/institutions/mskcc/> ;
  onco:pathways <https://onco.cc/pathways/keap1-nrf2/>, <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/pathways/t-cell-exhaustion/> ;
  onco:terms <https://onco.cc/terms/stk11-keap1/>, <https://onco.cc/terms/kras-mutation-subtypes/> ;
  onco:people <https://onco.cc/people/gregory-riely/> ;
  onco:journals <https://onco.cc/journals/clinical-cancer-research/> .