# OnCo record paper-ascent-nejm-2021 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-ascent-nejm-2021/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-ascent-nejm-2021" ;
  schema:name "ASCENT: sacituzumab govitecan doubles survival in heavily pretreated metastatic triple-negative breast cancer"@en ;
  schema:description "In triple-negative breast cancer that had already been through at least two treatments, the TROP2 antibody-drug conjugate sacituzumab govitecan roughly doubled the time patients lived compared with standard chemotherapy."@en ;
  schema:url <https://onco.cc/key-papers/paper-ascent-nejm-2021/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2028485>, <https://clinicaltrials.gov/study/NCT02574455> ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa2028485> ;
  schema:datePublished "2021"^^xsd:gYear ;
  schema:author "Bardia A, Hurvitz SA, Tolaney SM, et al." ;
  onco:related <https://onco.cc/ideas/idea-post-neoadjuvant-adc/>, <https://onco.cc/ideas/idea-trop2-pet-selection/> ;
  onco:cancers <https://onco.cc/cancers/tnbc/> ;
  onco:technologies <https://onco.cc/technologies/adc/>, <https://onco.cc/technologies/topoisomerase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/trop2/> ;
  onco:drugs <https://onco.cc/drugs/sacituzumab-govitecan/> ;
  onco:companies <https://onco.cc/companies/gilead/> ;
  onco:terms <https://onco.cc/terms/linker/>, <https://onco.cc/terms/payload/>, <https://onco.cc/terms/orr/>, <https://onco.cc/terms/pfs/>, <https://onco.cc/terms/os/>, <https://onco.cc/terms/accelerated-approval/> ;
  onco:trials <https://onco.cc/trials/ascent/>, <https://onco.cc/trials/ascent-03/>, <https://onco.cc/trials/ascent-04/> ;
  onco:people <https://onco.cc/people/sara-hurvitz/>, <https://onco.cc/people/sara-tolaney/>, <https://onco.cc/people/javier-cortes/>, <https://onco.cc/people/martine-piccart/>, <https://onco.cc/people/sibylle-loibl/>, <https://onco.cc/people/hope-rugo/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> ;
  onco:journals <https://onco.cc/journals/nejm/> .