# OnCo record paper-beltran-nepc-divergent-evolution-nat-med-2016 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
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<https://onco.cc/key-papers/paper-beltran-nepc-divergent-evolution-nat-med-2016/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-beltran-nepc-divergent-evolution-nat-med-2016" ;
  schema:name "Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer"@en ;
  schema:description "Sequencing showed that neuroendocrine prostate cancer arises from the same cells as ordinary prostate adenocarcinoma but diverges through loss of RB1 and TP53 and changes in DNA methylation rather than new mutations, explaining how the cancer escapes hormone therapy by changing identity."@en ;
  schema:url <https://onco.cc/key-papers/paper-beltran-nepc-divergent-evolution-nat-med-2016/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nm.4045>, <https://pubmed.ncbi.nlm.nih.gov/26855148/> ;
  schema:sameAs <https://doi.org/10.1038/nm.4045> ;
  schema:datePublished "2016"^^xsd:gYear ;
  schema:author "Beltran H, Prandi D, Mosquera JM, et al." ;
  onco:cancers <https://onco.cc/cancers/prostate-nepc/> ;
  onco:journals <https://onco.cc/journals/nature-medicine/> .