# OnCo record paper-bischoff-onyx-015-science-1996 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-bischoff-onyx-015-science-1996/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-bischoff-onyx-015-science-1996" ;
  schema:name "Bischoff 1996: the adenovirus that was said to replicate only where p53 was lost"@en ;
  schema:description "An adenovirus missing the gene that disables the cell's main tumour suppressor appeared to grow only in cancer cells that had already lost that suppressor, a claim that launched the field's first big clinical programme and was later shown to be the wrong explanation."@en ;
  schema:url <https://onco.cc/key-papers/paper-bischoff-onyx-015-science-1996/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1126/science.274.5286.373>, <https://pubmed.ncbi.nlm.nih.gov/8832876/>, <https://doi.org/10.1016/j.ccr.2004.11.012> ;
  schema:sameAs <https://doi.org/10.1126/science.274.5286.373> ;
  schema:datePublished "1996"^^xsd:gYear ;
  schema:author "Bischoff JR, Kirn DH, Williams A, et al." ;
  onco:sections <https://onco.cc/fronts/immunotherapy/> ;
  onco:technologies <https://onco.cc/technologies/oncolytic-virus/> ;
  onco:targets <https://onco.cc/targets/tp53/> ;
  onco:people <https://onco.cc/people/frank-mccormick/> ;
  onco:journals <https://onco.cc/journals/science/> .