# OnCo record paper-brca-risk-reducing-surgery-jama-2010 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-brca-risk-reducing-surgery-jama-2010/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-brca-risk-reducing-surgery-jama-2010" ;
  schema:name "PROSE consortium: preventive surgery lowers cancer and death in BRCA1 and BRCA2 carriers"@en ;
  schema:description "Among 2,482 women with BRCA1 or BRCA2 mutations, removing the ovaries and fallopian tubes was associated with 60% lower all-cause mortality, and no breast cancers occurred in the women who had preventive mastectomy."@en ;
  schema:url <https://onco.cc/key-papers/paper-brca-risk-reducing-surgery-jama-2010/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jama.2010.1237> ;
  schema:sameAs <https://doi.org/10.1001/jama.2010.1237> ;
  schema:datePublished "2010"^^xsd:gYear ;
  schema:author "Domchek SM, Friebel TM, Singer CF, et al." ;
  onco:related <https://onco.cc/ideas/idea-moon-population-germline-screening/>, <https://onco.cc/ideas/idea-prev-population-germline-screening-at-30/>, <https://onco.cc/ideas/idea-prev-brca1-denosumab-prevention/> ;
  onco:cancers <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/tnbc/> ;
  onco:sections <https://onco.cc/fronts/prevention/>, <https://onco.cc/fronts/surgery/> ;
  onco:technologies <https://onco.cc/technologies/germline-testing/> ;
  onco:targets <https://onco.cc/targets/brca/> ;
  onco:institutions <https://onco.cc/institutions/penn-abramson/> ;
  onco:terms <https://onco.cc/terms/germline-vs-somatic/> ;
  onco:people <https://onco.cc/people/susan-domchek/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-hereditary-risk/>, <https://onco.cc/bottlenecks/b-prevention-adoption/> ;
  onco:journals <https://onco.cc/journals/jama/> .
