# OnCo record paper-breakwater-nejm-2025 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-breakwater-nejm-2025/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-breakwater-nejm-2025" ;
  schema:name "BREAKWATER: encorafenib plus cetuximab with chemotherapy as first treatment for BRAF V600E-mutated colorectal cancer"@en ;
  schema:description "Adding a BRAF inhibitor and an EGFR antibody to first-line chemotherapy roughly doubled survival in BRAF V600E-mutated metastatic bowel cancer, one of the worst-prognosis subtypes."@en ;
  schema:url <https://onco.cc/key-papers/paper-breakwater-nejm-2025/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://pubmed.ncbi.nlm.nih.gov/?term=BREAKWATER+encorafenib+cetuximab+mFOLFOX6+colorectal>, <https://clinicaltrials.gov/study/NCT04607421> ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa2501912> ;
  schema:datePublished "2025"^^xsd:gYear ;
  schema:author "Elez E, Yoshino T, Shen L, et al." ;
  onco:related <https://onco.cc/biomarkers/braf-v600e/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/monoclonal-antibody/>, <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/cgp/> ;
  onco:targets <https://onco.cc/targets/braf/>, <https://onco.cc/targets/egfr/> ;
  onco:drugs <https://onco.cc/drugs/encorafenib/> ;
  onco:companies <https://onco.cc/companies/pfizer/> ;
  onco:institutions <https://onco.cc/institutions/vall-dhebron/>, <https://onco.cc/institutions/md-anderson/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:terms <https://onco.cc/terms/orr/>, <https://onco.cc/terms/pfs/>, <https://onco.cc/terms/os/>, <https://onco.cc/terms/first-line/>, <https://onco.cc/terms/accelerated-approval/> ;
  onco:people <https://onco.cc/people/elena-elez/>, <https://onco.cc/people/yoshino-takayuki/>, <https://onco.cc/people/shen-lin/>, <https://onco.cc/people/kim-tae-won/>, <https://onco.cc/people/josep-tabernero/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-combination-space/>, <https://onco.cc/bottlenecks/b-drug-pricing/> ;
  onco:journals <https://onco.cc/journals/nejm/> .