# OnCo record paper-bullock-botensilimab-balstilimab-mss-colorectal-nat-med-2024 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-bullock-botensilimab-balstilimab-mss-colorectal-nat-med-2024/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-bullock-botensilimab-balstilimab-mss-colorectal-nat-med-2024" ;
  schema:name "Botensilimab plus balstilimab in relapsed/refractory microsatellite stable metastatic colorectal cancer: a phase 1 trial"@en ;
  schema:description "The first immunotherapy signal in the 95 percent of bowel cancers that have always ignored it: an engineered CTLA-4 antibody plus a PD-1 antibody shrank tumours in 17 percent of 101 heavily treated patients."@en ;
  schema:url <https://onco.cc/key-papers/paper-bullock-botensilimab-balstilimab-mss-colorectal-nat-med-2024/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/s41591-024-03083-7>, <https://pubmed.ncbi.nlm.nih.gov/38871975/>, <https://europepmc.org/article/MED/38871975> ;
  onco:tag "colorectal-evidence" ;
  schema:sameAs <https://doi.org/10.1038/s41591-024-03083-7> ;
  schema:datePublished "2024"^^xsd:gYear ;
  schema:author "Bullock AJ, Schlechter BL, Fakih MG, et al." ;
  onco:related <https://onco.cc/ideas/idea-immunotherapy-mss-crc/>, <https://onco.cc/key-papers/paper-le-pd1-blockade-mismatch-repair-deficiency-nejm-2015/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:sections <https://onco.cc/fronts/immunotherapy/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/ctla4/>, <https://onco.cc/targets/pd1/> ;
  onco:drugs <https://onco.cc/drugs/botensilimab/>, <https://onco.cc/drugs/balstilimab/> ;
  onco:companies <https://onco.cc/companies/agenus/> ;
  onco:pathways <https://onco.cc/pathways/pd1-checkpoint/>, <https://onco.cc/pathways/cancer-immunity-cycle/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/terms/cold-vs-hot/>, <https://onco.cc/terms/mss-pmmr/> ;
  onco:people <https://onco.cc/people/heinz-josef-lenz/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-immunotherapy-response/>, <https://onco.cc/bottlenecks/b-tme-immunosuppression/> ;
  onco:journals <https://onco.cc/journals/nature-medicine/> .