# OnCo record paper-carver-pi3k-ar-reciprocal-feedback-prostate-cancer-cell-2011 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-carver-pi3k-ar-reciprocal-feedback-prostate-cancer-cell-2011/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-carver-pi3k-ar-reciprocal-feedback-prostate-cancer-cell-2011" ;
  schema:name "Reciprocal feedback regulation of PI3K and androgen receptor signalling in PTEN-deficient prostate cancer"@en ;
  schema:description "Two growth pathways in prostate cancer prop each other up: block one and the other switches on, which is why single drugs fail and the pair has to be blocked together."@en ;
  schema:url <https://onco.cc/key-papers/paper-carver-pi3k-ar-reciprocal-feedback-prostate-cancer-cell-2011/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/j.ccr.2011.04.008>, <https://pubmed.ncbi.nlm.nih.gov/21575859/> ;
  schema:sameAs <https://doi.org/10.1016/j.ccr.2011.04.008> ;
  schema:datePublished "2011"^^xsd:gYear ;
  schema:author "Carver BS, Chapinski C, Wongvipat J, et al." ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:targets <https://onco.cc/targets/pten/>, <https://onco.cc/targets/akt/>, <https://onco.cc/targets/androgen-receptor/>, <https://onco.cc/targets/pik3ca/> ;
  onco:pathways <https://onco.cc/pathways/pi3k-akt-mtor/>, <https://onco.cc/pathways/ar-signaling/>, <https://onco.cc/pathways/rtk-activation/>, <https://onco.cc/pathways/resistance-routes-map/> ;
  onco:terms <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/castration-resistance/> ;
  onco:journals <https://onco.cc/journals/cancer-cell/> .