# OnCo record paper-chapuy-molecular-subtypes-dlbcl-nat-med-2018 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-chapuy-molecular-subtypes-dlbcl-nat-med-2018/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-chapuy-molecular-subtypes-dlbcl-nat-med-2018" ;
  schema:name "Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes"@en ;
  schema:alternateName "Chapuy 2018"@en, "Five genetic clusters of diffuse large B-cell lymphoma"@en, "C1 to C5 clusters"@en ;
  schema:description "Reading the whole genetic picture of 304 lymphomas, rather than one gene at a time, sorted them into five groups that arise by different routes and respond differently."@en ;
  schema:url <https://onco.cc/key-papers/paper-chapuy-molecular-subtypes-dlbcl-nat-med-2018/> ;
  schema:dateModified "2026-10-01"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/s41591-018-0016-8>, <https://pubmed.ncbi.nlm.nih.gov/29713087/>, <https://europepmc.org/article/MED/29713087> ;
  onco:tag "lymphoma-evidence" ;
  schema:sameAs <https://doi.org/10.1038/s41591-018-0016-8> ;
  schema:datePublished "2018"^^xsd:gYear ;
  schema:author "Chapuy B, Stewart C, Dunford AJ, et al." ;
  onco:related <https://onco.cc/key-papers/paper-schmitz-genetics-pathogenesis-dlbcl-nejm-2018/>, <https://onco.cc/key-papers/paper-wright-lymphgen-genetic-subtypes-dlbcl-cancer-cell-2020/>, <https://onco.cc/roadmaps/lymphoma-roadmap/> ;
  onco:cancers <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:sections <https://onco.cc/fronts/diagnostics/>, <https://onco.cc/fronts/drug-discovery/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/terms/ngs/> ;
  onco:targets <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/cdkn2a/>, <https://onco.cc/targets/bcl2/>, <https://onco.cc/targets/bcl6/>, <https://onco.cc/targets/myd88/>, <https://onco.cc/targets/cd79b/>, <https://onco.cc/targets/notch2/> ;
  onco:institutions <https://onco.cc/institutions/dana-farber/> ;
  onco:terms <https://onco.cc/terms/cell-of-origin/>, <https://onco.cc/terms/ipi-score/>, <https://onco.cc/terms/tmb/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tumor-heterogeneity/>, <https://onco.cc/bottlenecks/b-biomarker-validation/>, <https://onco.cc/bottlenecks/b-translational-valley/> ;
  onco:journals <https://onco.cc/journals/nature-medicine/> .