# OnCo record paper-chen-androgen-receptor-overexpression-antiandrogen-resistance-nat-med-2004 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-chen-androgen-receptor-overexpression-antiandrogen-resistance-nat-med-2004/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-chen-androgen-receptor-overexpression-antiandrogen-resistance-nat-med-2004" ;
  schema:name "Molecular determinants of resistance to antiandrogen therapy"@en ;
  schema:alternateName "Chen 2004"@en, "AR overexpression antiandrogen resistance"@en, "Sawyers 2004 androgen receptor"@en ;
  schema:description "This study found the one change that always happened when prostate cancer became resistant to hormone-blocking drugs: the cell made more androgen receptor. With enough of it, the drugs that were meant to block the receptor started switching it on instead."@en ;
  schema:url <https://onco.cc/key-papers/paper-chen-androgen-receptor-overexpression-antiandrogen-resistance-nat-med-2004/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nm972>, <https://pubmed.ncbi.nlm.nih.gov/14702632/> ;
  onco:tag "prostate-evidence" ;
  schema:sameAs <https://doi.org/10.1038/nm972> ;
  schema:datePublished "2004"^^xsd:gYear ;
  schema:author "Chen CD, Welsbie DS, Tran C, et al." ;
  onco:related <https://onco.cc/key-papers/paper-visakorpi-androgen-receptor-amplification-nat-genet-1995/>, <https://onco.cc/key-papers/paper-attard-abiraterone-phase-1-cyp17-jco-2008/>, <https://onco.cc/roadmaps/prostate-roadmap/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:sections <https://onco.cc/fronts/hormonal/>, <https://onco.cc/fronts/targeted-therapy/>, <https://onco.cc/fronts/drug-discovery/> ;
  onco:targets <https://onco.cc/targets/androgen-receptor/> ;
  onco:drugs <https://onco.cc/drugs/enzalutamide/>, <https://onco.cc/drugs/bicalutamide/> ;
  onco:pathways <https://onco.cc/pathways/ar-signaling/>, <https://onco.cc/pathways/resistance-routes-map/>, <https://onco.cc/pathways/transcription-addiction/> ;
  onco:terms <https://onco.cc/terms/castration-resistance/>, <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/adt/> ;
  onco:people <https://onco.cc/people/charles-sawyers/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-preclinical-models/> ;
  onco:journals <https://onco.cc/journals/nature-medicine/> .