# OnCo record paper-chmielecki-acinar-cell-carcinoma-raf-fusions-dna-repair-cancer-discov-2014 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-chmielecki-acinar-cell-carcinoma-raf-fusions-dna-repair-cancer-discov-2014/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-chmielecki-acinar-cell-carcinoma-raf-fusions-dna-repair-cancer-discov-2014" ;
  schema:name "Chmielecki 2014: comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes"@en ;
  schema:description "Sequencing of acinar cell carcinomas found that they do not carry the KRAS mutation that drives ordinary pancreatic cancer; instead about a quarter have fusions activating BRAF or RAF1, which MEK-blocking drugs can shut down in the laboratory, and almost half have broken DNA repair genes that may make them sensitive to platinum and PARP inhibitors."@en ;
  schema:url <https://onco.cc/key-papers/paper-chmielecki-acinar-cell-carcinoma-raf-fusions-dna-repair-cancer-discov-2014/> ;
  schema:dateModified "2026-09-21"^^xsd:date ;
  schema:citation <https://doi.org/10.1158/2159-8290.CD-14-0617>, <https://pubmed.ncbi.nlm.nih.gov/25266736/> ;
  schema:sameAs <https://doi.org/10.1158/2159-8290.CD-14-0617> ;
  schema:datePublished "2014"^^xsd:gYear ;
  schema:author "Chmielecki J, Hutchinson KE, Frampton GM, et al." ;
  onco:cancers <https://onco.cc/cancers/pancreatic-acinar-cell-carcinoma/>, <https://onco.cc/cancers/pancreatic/> ;
  onco:journals <https://onco.cc/journals/cancer-discovery/> .