# OnCo record paper-clear-nejm-2021 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-clear-nejm-2021/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-clear-nejm-2021" ;
  schema:name "CLEAR: lenvatinib plus pembrolizumab versus sunitinib as first treatment for advanced kidney cancer"@en ;
  schema:description "Combining the multi-kinase inhibitor lenvatinib with pembrolizumab more than doubled the time to progression compared with sunitinib in advanced clear-cell kidney cancer and improved survival, with 71% of patients responding."@en ;
  schema:url <https://onco.cc/key-papers/paper-clear-nejm-2021/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2035716>, <https://clinicaltrials.gov/study/NCT02811861> ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa2035716> ;
  schema:datePublished "2021"^^xsd:gYear ;
  schema:author "Motzer R, Alekseev B, Rha SY, et al." ;
  onco:cancers <https://onco.cc/cancers/rcc/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/antiangiogenic/> ;
  onco:targets <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/vegf/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/> ;
  onco:companies <https://onco.cc/companies/merck/>, <https://onco.cc/companies/eli-lilly/> ;
  onco:terms <https://onco.cc/terms/pfs/>, <https://onco.cc/terms/os/>, <https://onco.cc/terms/orr/>, <https://onco.cc/terms/first-line/> ;
  onco:people <https://onco.cc/people/rha-sun-young/>, <https://onco.cc/people/toni-choueiri/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-combination-space/>, <https://onco.cc/bottlenecks/b-toxicity-qol/>, <https://onco.cc/bottlenecks/b-dose-optimisation/> ;
  onco:journals <https://onco.cc/journals/nejm/> .