# OnCo record paper-coates-sacituzumab-resistance-tacstd2-cancer-discov-2021 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-coates-sacituzumab-resistance-tacstd2-cancer-discov-2021/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-coates-sacituzumab-resistance-tacstd2-cancer-discov-2021" ;
  schema:name "Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer"@en ;
  schema:description "When triple-negative breast cancer became resistant to sacituzumab govitecan in one patient, one branch of the tumour had changed the drug's payload target and a different branch had changed TROP2 itself."@en ;
  schema:url <https://onco.cc/key-papers/paper-coates-sacituzumab-resistance-tacstd2-cancer-discov-2021/> ;
  schema:dateModified "2026-11-04"^^xsd:date ;
  schema:citation <https://doi.org/10.1158/2159-8290.CD-21-0702>, <https://pubmed.ncbi.nlm.nih.gov/34404686/> ;
  schema:sameAs <https://doi.org/10.1158/2159-8290.CD-21-0702> ;
  schema:datePublished "2021"^^xsd:gYear ;
  schema:author "Coates JT, Sun S, Leshchiner I, et al." ;
  onco:cancers <https://onco.cc/cancers/tnbc/> ;
  onco:sections <https://onco.cc/fronts/adcs/> ;
  onco:targets <https://onco.cc/targets/trop2/> ;
  onco:drugs <https://onco.cc/drugs/sacituzumab-govitecan/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-subclone-attribution-residual-disease/> ;
  onco:journals <https://onco.cc/journals/cancer-discovery/> .