# OnCo record paper-cowzer-biliary-targeted-therapy-determinants-ccr-2026 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
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<https://onco.cc/key-papers/paper-cowzer-biliary-targeted-therapy-determinants-ccr-2026/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-cowzer-biliary-targeted-therapy-determinants-ccr-2026" ;
  schema:name "Molecular and clinical determinants of targeted therapy treatment in biliary tract cancer"@en ;
  schema:description "In 1,254 biliary cancer patients sequenced at one centre, a third had a top-tier druggable change (22% of gallbladder cancers), targeted drugs delayed progression but did not lengthen life, and HER2-driven tumours sometimes lost HER2 at relapse."@en ;
  schema:url <https://onco.cc/key-papers/paper-cowzer-biliary-targeted-therapy-determinants-ccr-2026/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1158/1078-0432.ccr-26-0428>, <https://pubmed.ncbi.nlm.nih.gov/42360806/>, <https://www.cbioportal.org/study/summary?id=biliary_tract_msk_2026> ;
  schema:sameAs <https://doi.org/10.1158/1078-0432.ccr-26-0428> ;
  schema:datePublished "2026"^^xsd:gYear ;
  schema:author "Cowzer D, Walch H, Atri P, et al." ;
  onco:cancers <https://onco.cc/cancers/gallbladder/>, <https://onco.cc/cancers/cholangiocarcinoma/>, <https://onco.cc/cancers/biliary-tract-cancer/> ;
  onco:targets <https://onco.cc/targets/her2/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/mdm2/>, <https://onco.cc/targets/smad4/>, <https://onco.cc/targets/cdkn2a/> ;
  onco:institutions <https://onco.cc/institutions/mskcc/> ;
  onco:people <https://onco.cc/people/ghassan-abou-alfa/> ;
  onco:journals <https://onco.cc/journals/clinical-cancer-research/> .