# OnCo record paper-de-bono-tropic-cabazitaxel-lancet-2010 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-de-bono-tropic-cabazitaxel-lancet-2010/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-de-bono-tropic-cabazitaxel-lancet-2010" ;
  schema:name "TROPIC: prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel"@en ;
  schema:alternateName "TROPIC"@en, "de Bono 2010 cabazitaxel"@en ;
  schema:description "The first drug shown to extend life after docetaxel has stopped working. Cabazitaxel, a taxane designed to get past the pumps that expel docetaxel from resistant cells, added about two and a half months, at the cost of a high rate of low white cell counts."@en ;
  schema:url <https://onco.cc/key-papers/paper-de-bono-tropic-cabazitaxel-lancet-2010/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/s0140-6736(10)61389-x>, <https://pubmed.ncbi.nlm.nih.gov/20888992/>, <https://clinicaltrials.gov/study/NCT00417079> ;
  onco:tag "prostate-evidence" ;
  schema:sameAs <https://doi.org/10.1016/s0140-6736(10)61389-x> ;
  schema:datePublished "2010"^^xsd:gYear ;
  schema:author "de Bono JS, Oudard S, Ozguroglu M, et al." ;
  onco:related <https://onco.cc/key-papers/paper-tannock-tax-327-docetaxel-prednisone-nejm-2004/>, <https://onco.cc/key-papers/paper-scher-affirm-enzalutamide-nejm-2012/>, <https://onco.cc/roadmaps/chemotherapy-roadmap/>, <https://onco.cc/roadmaps/prostate-roadmap/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:sections <https://onco.cc/fronts/chemotherapy/> ;
  onco:drugs <https://onco.cc/drugs/cabazitaxel/>, <https://onco.cc/drugs/docetaxel/>, <https://onco.cc/drugs/mitoxantrone/>, <https://onco.cc/drugs/prednisone/> ;
  onco:companies <https://onco.cc/companies/sanofi/> ;
  onco:terms <https://onco.cc/terms/castration-resistance/>, <https://onco.cc/terms/hazard-ratio/> ;
  onco:people <https://onco.cc/people/johann-de-bono/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> ;
  onco:journals <https://onco.cc/journals/lancet/> .