# OnCo record paper-depmap-tsherniak-cell-2017 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-depmap-tsherniak-cell-2017/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-depmap-tsherniak-cell-2017" ;
  schema:name "Defining a Cancer Dependency Map: which genes each cancer cell line cannot live without"@en ;
  schema:description "Genome-scale RNAi screens across 501 cancer cell lines, analysed with the DEMETER algorithm to remove off-target noise, identified 769 genes on which subsets of cancers depend and showed that most dependencies can be predicted from the cell's molecular features."@en ;
  schema:url <https://onco.cc/key-papers/paper-depmap-tsherniak-cell-2017/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/j.cell.2017.06.010>, <https://doi.org/10.1038/ng.3984>, <https://depmap.org> ;
  schema:sameAs <https://doi.org/10.1016/j.cell.2017.06.010> ;
  schema:datePublished "2017"^^xsd:gYear ;
  schema:author "Tsherniak A, Vazquez F, Montgomery PG, et al." ;
  onco:related <https://onco.cc/collections/depmap/>, <https://onco.cc/technologies/high-throughput-screening-libraries/> ;
  onco:sections <https://onco.cc/fronts/drug-discovery/> ;
  onco:technologies <https://onco.cc/technologies/crispr-screens/>, <https://onco.cc/technologies/synthetic-lethality-approaches/>, <https://onco.cc/technologies/functional-drug-testing/> ;
  onco:targets <https://onco.cc/targets/wrn/>, <https://onco.cc/targets/prmt5-mtap/> ;
  onco:institutions <https://onco.cc/institutions/broad-institute/>, <https://onco.cc/institutions/dana-farber/> ;
  onco:terms <https://onco.cc/terms/synthetic-lethality/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-preclinical-models/>, <https://onco.cc/bottlenecks/b-undruggable-targets/>, <https://onco.cc/bottlenecks/b-translational-valley/> ;
  onco:journals <https://onco.cc/journals/cell/> .