# OnCo record paper-destiny-breast03-nejm-2022 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-destiny-breast03-nejm-2022/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-destiny-breast03-nejm-2022" ;
  schema:name "DESTINY-Breast03: trastuzumab deruxtecan beats T-DM1 as second-line treatment of HER2-positive metastatic breast cancer"@en ;
  schema:description "A newer antibody-drug conjugate, trastuzumab deruxtecan, kept HER2-positive metastatic breast cancer under control roughly four times longer than the previous standard, T-DM1, and later lengthened survival."@en ;
  schema:url <https://onco.cc/key-papers/paper-destiny-breast03-nejm-2022/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2115022>, <https://clinicaltrials.gov/study/NCT03529110> ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa2115022> ;
  schema:datePublished "2022"^^xsd:gYear ;
  schema:author "Cortes J, Kim SB, Chung WP, et al." ;
  onco:related <https://onco.cc/ideas/idea-payload-switching/> ;
  onco:cancers <https://onco.cc/cancers/breast-her2-positive/> ;
  onco:technologies <https://onco.cc/technologies/adc/>, <https://onco.cc/technologies/topoisomerase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/her2/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab-deruxtecan/>, <https://onco.cc/drugs/trastuzumab-emtansine/> ;
  onco:companies <https://onco.cc/companies/daiichi-sankyo/>, <https://onco.cc/companies/astrazeneca/> ;
  onco:terms <https://onco.cc/terms/pfs/>, <https://onco.cc/terms/os/>, <https://onco.cc/terms/payload/>, <https://onco.cc/terms/dar/>, <https://onco.cc/terms/bystander-effect/>, <https://onco.cc/terms/ild/>, <https://onco.cc/terms/adc-sequencing/> ;
  onco:trials <https://onco.cc/trials/destiny-breast03/> ;
  onco:people <https://onco.cc/people/javier-cortes/>, <https://onco.cc/people/kim-sung-bae/>, <https://onco.cc/people/im-seock-ah/>, <https://onco.cc/people/park-yeon-hee/>, <https://onco.cc/people/giuseppe-curigliano/>, <https://onco.cc/people/xu-binghe/>, <https://onco.cc/people/sara-hurvitz/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> ;
  onco:journals <https://onco.cc/journals/nejm/> .