# OnCo record paper-destiny-breast04-nejm-2022 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-destiny-breast04-nejm-2022/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-destiny-breast04-nejm-2022" ;
  schema:name "DESTINY-Breast04: trastuzumab deruxtecan works in HER2-low breast cancer, creating a new treatable group"@en ;
  schema:description "Breast cancers with only a little HER2 on their surface, long called HER2-negative, responded to trastuzumab deruxtecan and patients lived about six months longer than on chemotherapy. It created the HER2-low category."@en ;
  schema:url <https://onco.cc/key-papers/paper-destiny-breast04-nejm-2022/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2203690>, <https://clinicaltrials.gov/study/NCT03734029> ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa2203690> ;
  schema:datePublished "2022"^^xsd:gYear ;
  schema:author "Modi S, Jacot W, Yamashita T, et al." ;
  onco:related <https://onco.cc/ideas/idea-payload-switching/>, <https://onco.cc/biomarkers/her2-low-ihc/> ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/tnbc-metastatic/> ;
  onco:technologies <https://onco.cc/technologies/adc/>, <https://onco.cc/technologies/histopathology-ihc/>, <https://onco.cc/technologies/companion-diagnostic/> ;
  onco:targets <https://onco.cc/targets/her2/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab-deruxtecan/> ;
  onco:companies <https://onco.cc/companies/daiichi-sankyo/>, <https://onco.cc/companies/astrazeneca/> ;
  onco:terms <https://onco.cc/terms/her2-low/>, <https://onco.cc/terms/ihc/>, <https://onco.cc/terms/bystander-effect/>, <https://onco.cc/terms/ild/>, <https://onco.cc/terms/pfs/>, <https://onco.cc/terms/os/> ;
  onco:trials <https://onco.cc/trials/destiny-breast04/> ;
  onco:people <https://onco.cc/people/sohn-joohyuk/>, <https://onco.cc/people/park-yeon-hee/>, <https://onco.cc/people/xu-binghe/>, <https://onco.cc/people/im-seock-ah/>, <https://onco.cc/people/hope-rugo/>, <https://onco.cc/people/kim-sung-bae/>, <https://onco.cc/people/david-cameron/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-biomarker-validation/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> ;
  onco:journals <https://onco.cc/journals/nejm/> .