# OnCo record paper-destiny-breast06-nejm-2024 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-destiny-breast06-nejm-2024/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-destiny-breast06-nejm-2024" ;
  schema:name "DESTINY-Breast06: trastuzumab deruxtecan before any chemotherapy in hormone-receptor-positive, HER2-low or ultralow breast cancer"@en ;
  schema:description "Given as the first chemotherapy-type treatment after hormone therapy stopped working, trastuzumab deruxtecan delayed progression by about five months compared with standard chemotherapy, including in tumours with barely detectable HER2."@en ;
  schema:url <https://onco.cc/key-papers/paper-destiny-breast06-nejm-2024/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://pubmed.ncbi.nlm.nih.gov/?term=DESTINY-Breast06+trastuzumab+deruxtecan+HER2-low+chemotherapy-naive>, <https://clinicaltrials.gov/study/NCT04494425> ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa2407086> ;
  schema:datePublished "2024"^^xsd:gYear ;
  schema:author "Bardia A, Hu X, Dent R, et al." ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/> ;
  onco:technologies <https://onco.cc/technologies/adc/>, <https://onco.cc/technologies/histopathology-ihc/> ;
  onco:targets <https://onco.cc/targets/her2/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab-deruxtecan/> ;
  onco:companies <https://onco.cc/companies/daiichi-sankyo/>, <https://onco.cc/companies/astrazeneca/> ;
  onco:terms <https://onco.cc/terms/her2-low/>, <https://onco.cc/terms/ihc/>, <https://onco.cc/terms/pfs/>, <https://onco.cc/terms/ild/>, <https://onco.cc/terms/first-line/> ;
  onco:trials <https://onco.cc/trials/destiny-breast06/> ;
  onco:people <https://onco.cc/people/hu-xichun/>, <https://onco.cc/people/yonemori-kan/>, <https://onco.cc/people/barrios-carlos/>, <https://onco.cc/people/sohn-joohyuk/>, <https://onco.cc/people/im-seock-ah/>, <https://onco.cc/people/giuseppe-curigliano/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-biomarker-validation/>, <https://onco.cc/bottlenecks/b-drug-pricing/>, <https://onco.cc/bottlenecks/b-trial-design/> ;
  onco:journals <https://onco.cc/journals/nejm/> .