# OnCo record paper-domingo-somatic-pole-proofreading-colorectal-lancet-gastro-2016 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
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<https://onco.cc/key-papers/paper-domingo-somatic-pole-proofreading-colorectal-lancet-gastro-2016/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-domingo-somatic-pole-proofreading-colorectal-lancet-gastro-2016" ;
  schema:name "Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer"@en ;
  schema:description "Pooling trials and cohorts covering 6,517 bowel cancers found that one in a hundred has a broken proofreading enzyme. Those tumours carry far more mutations than any other, attract as many immune cells as the mismatch repair deficient ones, and relapse far less often."@en ;
  schema:url <https://onco.cc/key-papers/paper-domingo-somatic-pole-proofreading-colorectal-lancet-gastro-2016/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/S2468-1253(16)30014-0>, <https://pubmed.ncbi.nlm.nih.gov/28404093/> ;
  schema:sameAs <https://doi.org/10.1016/S2468-1253(16)30014-0> ;
  schema:datePublished "2016"^^xsd:gYear ;
  schema:author "Domingo E, Freeman-Mills L, Rayner E, et al." ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/technologies/tmb-testing/> ;
  onco:targets <https://onco.cc/targets/pole/>, <https://onco.cc/targets/mmr/> ;
  onco:institutions <https://onco.cc/institutions/oxford-cancer/> ;
  onco:pathways <https://onco.cc/pathways/replication-stress/>, <https://onco.cc/pathways/mismatch-repair-msi/>, <https://onco.cc/pathways/cancer-immunity-cycle/> ;
  onco:terms <https://onco.cc/terms/pole-ultramutation/>, <https://onco.cc/terms/tmb/>, <https://onco.cc/terms/mss-pmmr/>, <https://onco.cc/terms/neoantigen/> ;
  onco:journals <https://onco.cc/journals/lancet/> .