# OnCo record paper-douillard-prime-panitumumab-ras-nejm-2013 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-douillard-prime-panitumumab-ras-nejm-2013/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-douillard-prime-panitumumab-ras-nejm-2013" ;
  schema:name "Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer (PRIME)"@en ;
  schema:description "Looking beyond the one KRAS exon everyone tested found that a further 17 percent of patients carried a RAS mutation and were harmed rather than helped by the antibody. Testing widened overnight."@en ;
  schema:url <https://onco.cc/key-papers/paper-douillard-prime-panitumumab-ras-nejm-2013/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1305275>, <https://pubmed.ncbi.nlm.nih.gov/24024839/> ;
  onco:tag "colorectal-evidence" ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa1305275> ;
  schema:datePublished "2013"^^xsd:gYear ;
  schema:author "Douillard JY, Oliner KS, Siena S, et al." ;
  onco:related <https://onco.cc/key-papers/paper-van-cutsem-crystal-cetuximab-folfiri-nejm-2009/>, <https://onco.cc/key-papers/paper-arnold-primary-tumour-side-ras-wild-type-ann-oncol-2017/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/> ;
  onco:technologies <https://onco.cc/technologies/monoclonal-antibody/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/braf/> ;
  onco:drugs <https://onco.cc/drugs/panitumumab/>, <https://onco.cc/drugs/folfox/>, <https://onco.cc/drugs/oxaliplatin/> ;
  onco:companies <https://onco.cc/companies/amgen/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:terms <https://onco.cc/terms/sidedness/> ;
  onco:people <https://onco.cc/people/salvatore-siena/>, <https://onco.cc/people/josep-tabernero/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-biomarker-validation/> ;
  onco:journals <https://onco.cc/journals/nejm/> .
